Open AccessInduction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models
Author(s) -
Haiqiong Zheng,
Jiabing Rong,
Feiming Ye,
Yinchuan Xu,
Hong Lü,
Jianan Wang
Publication year - 2020
Publication title -
journal of zhejiang university. science b
Language(s) - English
Resource type - Journals
eISSN - 1862-1783
pISSN - 1673-1581
DOI - 10.1631/jzus.b2000022
Subject(s) - aortic dissection , angiotensin ii , pathogenesis , medicine , dissection (medical) , aorta , surgery , receptor
Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.