DNA Methylation in T-Cell Development and Differentiation | Zendy

Luis O. Correa | Zendy; Martha S. Jordan | Zendy; Shan A. Carty | Zendy

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DNA Methylation in T-Cell Development and Differentiation

Author(s) -

Luis O. Correa,

Martha S. Jordan,

Shan A. Carty

Publication year - 2020

Publication title -

critical reviews in immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.997

H-Index - 75

eISSN - 2162-6472

pISSN - 1040-8401

DOI - 10.1615/critrevimmunol.2020033728

Subject(s) - dna methylation , epigenetics , epigenomics , dna methyltransferase , histone , biology , histone methylation , epigenetics of physical exercise , histone methyltransferase , methyltransferase , cellular differentiation , context (archaeology) , dna , microbiology and biotechnology , methylation , genetics , gene , gene expression , paleontology

T lymphocytes undergo carefully orchestrated programming during development in the thymus and subsequently during differentiation in the periphery. This intricate specification allows for cell-type and context-specific transcriptional programs that regulate immune responses to infection and malignancy. Epigenetic changes, including histone modifications and covalent modification of DNA itself through DNA methylation, are now recognized to play a critical role in these cell-fate decisions. DNA methylation is mediated primarily by the actions of the DNA methyltransferase (DNMT) and ten-eleven-translocation (TET) families of epigenetic enzymes. In this review, we discuss the role of DNA methylation and its enzymatic regulators in directing the development and differentiation of CD4+ and CD8+ T-cells.

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