Open AccessCD28-CD80/86 and CD40-CD40L Interactions Promote Thymic Tolerance by Regulating Medullary Epithelial Cell and Thymocyte Development
Author(s) -
Joy Williams,
Xuguang Tai,
Richard J. Hodes
Publication year - 2015
Publication title -
critical reviews in immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 75
eISSN - 2162-6472
pISSN - 1040-8401
DOI - 10.1615/critrevimmunol.2015012501
Subject(s) - cd80 , cd28 , cd40 , thymocyte , biology , microbiology and biotechnology , immunology , t cell , central tolerance , cytotoxic t cell , immune system , genetics , in vitro
Development and central tolerance of T lymphocytes in the thymus requires both TCR signals and collaboration with signals generated through costimulatory molecule interactions. In this review, we discuss the importance of CD28-CD80/86 and CD40-CD40L costimulatory interactions in promoting normal thymic development. This discussion includes roles in the generation of a normal thymic medulla, in the development of specific T-cells subsets, including iNKT and T regulatory cells, and in the generation of a tolerant mature T-cell repertoire. We discuss recent contributions to the understanding of CD28-CD80/86 and CD40-CD40L costimulatory interactions in thymic development, and we highlight the ways in which the many important roles mediated by these interactions collaborate to promote normal thymic development.