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Statistically Significant Increase in Weight Caused by Low‐Dose Quetiapine
Author(s) -
Williams Scott G.,
Alinejad Nima A.,
Williams Jeannie A.,
Cruess David F.
Publication year - 2010
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.30.10.1011
Subject(s) - quetiapine , weight gain , medicine , quetiapine fumarate , active duty , population , body weight , military personnel , psychiatry , environmental health , political science , atypical antipsychotic , schizophrenia (object oriented programming) , antipsychotic , law
Study Objective. To determine if preliminary data suggest that low‐dose quetiapine is associated with weight gain. Design. Retrospective medical record review. Setting. Two military hospitals serving active‐duty soldiers, family members of service members, and military retirees. Patients. Five hundred thirty‐four adult military health care beneficiaries who received quetiapine at a total daily dose of 100 mg or less for a minimum of 1 month between January 1, 2005, and June 30, 2008. Measurements and Main Results. The mean weight at baseline was 175.68 lbs. The mean ± standard error weight gain compared with baseline was 0.49 ± 0.51 lbs (p=0.335) at 1 month, increasing in a generally linear fashion to 5.56 ± 1.25 lbs (p<0.001) at 6 months, and 10.58 ± 2.20 lbs (p<0.001) at 12 months. Conclusion. Low‐dose quetiapine caused a statistically significant weight gain in our study population. This finding highlights the need for greater recognition of the potential for quetiapine to cause undesirable effects, and demonstrates the importance of close monitoring of physiologic parameters during treatment.