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Hemodynamic and Cognitive Effects of Lofexidine and Methadone Coadministration: A Pilot Study
Author(s) -
Schroeder Jennifer R.,
Schmittner John,
Bleiberg Joseph,
Epstein David H.,
Krantz Mori J.,
Preston Kenzie L.
Publication year - 2007
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.27.8.1111
Subject(s) - tolerability , medicine , methadone , anesthesia , orthostatic vital signs , placebo , blood pressure , adverse effect , hemodynamics , heart rate , alternative medicine , pathology
Study Objective . To determine the hemodynamic and cognitive effects of lofexidine and methadone coadministration. Design . Prospective, double‐blind study. Setting . Outpatient drug treatment research clinic. Subjects . Fourteen participants (aged 18–45 yrs) with physical dependence on opioids. Intervention . Subjects were stabilized on methadone maintenance therapy, starting with 30 mg/day and increasing by 10‐mg/day increments, based on each subject's tolerability to achieve a target dose of 80 mg/day. After 3 weeks of methadone stabilization, lofexidine 0.4 mg/day or matching placebo were coadministered with methadone, in doses escalating by 0.2‐mg/week increments, to achieve a target dose of 1.6 mg/day over the next 8 weeks. Measurements and Main Results . Acute orthostatic vital signs and neuropsychological effects of lofexidine and methadone coadministration were monitored for 5 hours after the dose on the first day of each new lofexidine dose. Orthostatic vital signs and adverse events were assessed daily thereafter to determine the effects of repeated doses. Lofexidine significantly decreased sitting systolic and diastolic blood pressure (p=0.045 and p=0.033, respectively) compared with placebo (i.e., methadone alone). With lofexidine 0.4 mg/day, mean decreases in systolic and diastolic blood pressure were 27 ± 17 and 15 ± 16 mm Hg, respectively. No significant association was noted between changes in orthostatic vital signs and lofexidine dose. Decreased cognitive efficiency was associated with lofexidine administration, and higher lofexidine doses adversely affected performance on a mathematical task compared with placebo (p=0.0035). The rate of adverse events was no higher with lofexidine than with placebo; the majority (54.3%) were common adverse effects of lofexidine. Conclusion . Significant changes in hemodynamic and cognitive efficiency were observed with coadministration of lofexidine and methadone compared with methadone alone. When patients receiving methadone are prescribed lofexidine, they should be closely monitored for cardiovascular and cognitive changes.