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Meta‐Analysis of Azelastine Nasal Spray for the Treatment of Allergic Rhinitis
Author(s) -
Lee Todd A.,
Pickard A. Simon
Publication year - 2007
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.27.6.852
Subject(s) - azelastine , nasal spray , medicine , dermatology , nasal administration , pharmacology
Study Objective . To systematically review the efficacy of azelastine nasal spray for the treatment of allergic rhinitis. Design . Meta‐analysis of published randomized controlled trials reported in English. Data Source . Published literature from the PubMed‐MEDLINE database. Patients . Patients aged at least 12 (United States) or 16 years (Europe) with allergic rhinitis or nonallergic vasomotor rhinitis. Measurements and Main Results . A global assessment of efficacy was used to estimate the number needed to treat for azelastine nasal spray compared with placebo or active comparators. The total symptom score was used to compare the effect size between azelastine and placebo. In five comparisons of azelastine and placebo, azelastine was most efficacious, with a summary number needed to treat of 5.0 (95% confidence interval [CI] 3.3–10.0). In reviewing 11 studies of azelastine versus active comparators, we found no significant difference between azelastine and active comparators (number needed to treat 66.7, 95% CI 14.3 to ∞ to 25]). Azelastine was more efficacious than placebo in terms of total symptom score (effect size of 0.36, 95% CI 0.26–0.46). Conclusion . Azelastine nasal spray was more efficacious than placebo in the treatment of allergic rhinitis. No significant differences were observed between azelastine and active comparators for the treatment of allergic rhinitis; however, when azelastine was compared with oral antihistamines as monotherapy, the trend favored azelastine. Because azelastine appears to be as efficacious as oral antihistamines, the choice of treatment for seasonal allergic rhinitis should depend on the patient's preference regarding the route of administration, adverse effects, and the cost of the drug.