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Controversy and Conflict in the Treatment of Acute Decompensated Heart Failure: Nesiritide as Evidence‐Based Treatment
Author(s) -
Munger Mark A.,
Ng Tien M. H.,
Tassell Benjamin W.
Publication year - 2007
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.27.5.619
Subject(s) - nesiritide , acute decompensated heart failure , heart failure , medicine , intensive care medicine , cardiology , natriuretic peptide
Acute decompensated heart failure poses a complex clinical challenge for the health care community. Evolving concepts of the pathophysiology and lack of consensus on appropriate outcome measures for drug approval underlie some of the current controversies about nesiritide. We outline the major controversies from the viewpoint that nesiritide should continue to be used judiciously by following its package insert recommendations and the Heart Failure Society of America's 2006 Comprehensive Heart Failure Practice Guidelines.