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Successful Treatment of Klebsiella rhinoscleromatis Bacteremia with Levofloxacin
Author(s) -
Pound Melanie W.,
Fulton Kathey B.,
Chima Chukwuemeka O.
Publication year - 2007
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.27.1.161
Subject(s) - levofloxacin , medicine , cefazolin , bacteremia , blood culture , rhinoscleroma , gentamicin , klebsiella pneumoniae , ampicillin , surgery , antibiotics , microbiology and biotechnology , pathology , biology , biochemistry , escherichia coli , gene
A 71‐year‐old Caucasian woman was admitted to the hospital with right‐sided weakness and slurred speech. Glioblastoma multiforme was diagnosed, and resection of the tumor was performed. During the patient's hospitalization, blood and urine cultures were obtained after her temperature rose to 103.3°F. Four blood cultures revealed Klebsiella rhinoscleromatis sensitive to trimethoprim‐sulfamethoxazole, levofloxacin, cefazolin, gentamicin, and tetracycline, but resistant to ampicillin. The patient had no recent history of foreign travel. After a 3‐week course with levofloxacin, the patient was afebrile, and repeat blood cultures were negative. To our knowledge, this was the first case of K. rhinoscleromatis bacteremia in the United States to be treated successfully with levofloxacin.