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Interaction Between Warfarin and Cranberry Juice
Author(s) -
Aston Jonathan L.,
Lodolce Amy E.,
Shapiro Nancy L.
Publication year - 2006
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.26.9.1314
Subject(s) - cranberry juice , warfarin , medicine , ingestion , fruit juice , urinary system , intensive care medicine , food science , atrial fibrillation , chemistry
Warfarin is extensively used for anticoagulation to a target international normalized ratio of 2.0–3.0 for most indications or 2.5–3.5 for high‐risk indications; however, many drugs and dietary supplements induce fluctuations in the international normalized ratio. Such fluctuations may lead to therapeutic failure or bleeding complications. Cranberry juice is increasingly used for the prevention and adjunctive treatment of urinary tract infections. The United Kingdom's Committee on Safety of Medicines has alerted clinicians to a potential interaction between warfarin and cranberry juice and has advised that patients avoid their concurrent use. Review and analysis of the literature revealed that ingestion of large volumes of cranberry juice destabilize warfarin therapy. Small amounts of juice are not expected to cause such an interaction. Clinicians should be aware of this potential interaction and monitor and counsel patients accordingly.