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Lepirudin Anticoagulation for Heparin‐Induced Thrombocytopenia After Cardiac Surgery in a Pediatric Patient
Author(s) -
Knoderer Chad A.,
Knoderer Holly M.,
Turrentine Mark W.,
Kumar Manjusha
Publication year - 2006
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.26.5.709
Subject(s) - lepirudin , medicine , extracorporeal membrane oxygenation , heparin induced thrombocytopenia , heparin , surgery , cardiac surgery , anticoagulant , population , anesthesia , discovery and development of direct thrombin inhibitors , platelet , thrombin , environmental health
A 21‐month‐old boy received anticoagulation with lepirudin for heparin‐induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.