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Azacitidine‐Induced Interstitial and Alveolar Fibrosis in a Patient with Myelodysplastic Syndrome
Author(s) -
Adams Christopher D.,
Szumita Paul M.,
Baroletti Steven A.,
Lilly Craig M.
Publication year - 2005
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.25.5.765.63579
Subject(s) - azacitidine , medicine , concomitant , pulmonary fibrosis , regimen , population , adverse effect , fibrosis , oncology , biology , biochemistry , gene expression , environmental health , gene , dna methylation
A 71‐year‐old Caucasian man diagnosed with myelodysplastic syndrome developed interstitial and alveolar fibrosis after receiving a 7‐day course of azacitidine therapy. The patient's pulmonary function began to deteriorate immediately after the administration of his chemotherapy regimen. Other potential causes of pulmonary toxicity were ruled out such as viral, fungal, and bacterial pathogens, as well as other concomitant drugs. To our knowledge, this is the first case report documenting biopsy‐proven interstitial and alveolar fibrosis associated with azacitidine. The frequency of this adverse drug reaction is unknown but may become more evident with increasing exposure of the population to azacitidine.