Premium
Use of Highly Active Antiretroviral Therapy in Patients with Renal Insufficiency
Author(s) -
Duggan Joan M.,
Sahloff Eric G.,
Moudgal Varsha V.
Publication year - 2005
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.25.5.698.63588
Subject(s) - medicine , renal function , antiretroviral therapy , human immunodeficiency virus (hiv) , reverse transcriptase , population , creatinine , antiretroviral drug , intensive care medicine , viral load , immunology , biology , environmental health , rna , biochemistry , gene
Antiretroviral agents, especially nucleoside reverse transcriptase inhibitors, require significant dosage adjustments in patients who have renal dysfunction and the human immunodeficiency virus (HIV). Some antiretroviral agents and fixed combination preparations are contraindicated in this population. In addition, many preferred antiretroviral regimens may be difficult to administer conveniently in patients with decreased creatinine clearance or in those receiving renal replacement therapies. Some highly active antiretroviral therapy regimens, however, can be used conveniently in patients with HIV and altered renal function.