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Levofloxacin Secretion in Breast Milk: A Case Report
Author(s) -
Cahill John B.,
Bailey Elaine M.,
Chien Shuchean,
Johnson George M.
Publication year - 2005
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.25.1.116.55616
Subject(s) - levofloxacin , discontinuation , pharmacokinetics , medicine , breast milk , ofloxacin , breast feeding , population , pharmacology , antibacterial agent , physiology , antibiotics , ciprofloxacin , microbiology and biotechnology , chemistry , biology , pediatrics , biochemistry , environmental health
Objective. To evaluate levofloxacin secretion in human breast milk. Methods. Breast milk was collected from a lactating woman during a 23‐day period in which she received levofloxacin 500 mg/day and for 5 days after discontinuation of levofloxacin. The levofloxacin concentration was assayed by high‐performance liquid chromatography. A two‐compartment pharmacokinetic model was used to estimate peak and total levofloxacin exposure. Results. At steady state, peak levofloxacin exposure in breast milk was 8.2 μg/ml at 5 hours after dosing. Elimination pharmacokinetics followed the anticipated pattern. Conclusion. Peak levofloxacin concentration in human breast milk is similar to levels attained in plasma. However, breast‐feeding mothers who take levofloxacin will expose their infants to levofloxacin in concentrations below those being studied in the pediatric population.