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Tenofovir‐Related Nephrotoxicity: Case Report and Review of the Literature
Author(s) -
James Christopher W.,
Steinhaus Mary C.,
Szabo Susan,
Dressler Robert M.
Publication year - 2004
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.24.4.415.33182
Subject(s) - fanconi syndrome , tenofovir , nephrotoxicity , discontinuation , reverse transcriptase , medicine , reverse transcriptase inhibitor , renal function , human immunodeficiency virus (hiv) , complication , virology , antiretroviral therapy , kidney , biology , viral load , genetics , rna , gene
Tenofovir is a nucleotide reverse transcriptase inhibitor for treatment of human immunodeficiency virus (HIV) infection. Several cases of renal failure associated with tenofovir therapy recently have been reported. A 54‐year‐old man with HIV experienced decreasing renal function and Fanconi's syndrome secondary to tenofovir therapy. His condition gradually improved after discontinuation of the drug. The available medical literature for reported cases of tenofovir‐related nephrotoxicity indicates that this complication is apparently rare. However, our case report and literature review underscore the importance of monitoring renal function when treating patients with any nucleotide reverse transcriptase inhibitor.