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The Impact of Antibiotic Management on Resistance
Author(s) -
Bosso John A.
Publication year - 2004
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.24.18.224s.52233
Subject(s) - presumption , antibiotic resistance , antibiotics , resistance (ecology) , subject (documents) , risk analysis (engineering) , business , biology , political science , computer science , law , microbiology and biotechnology , ecology , library science
The misguided presumption that a simple inverse relationship exists between the use of antibiotics and the emergence of bacterial resistance (i.e., increasing antibiotic use equals decreasing susceptibility and vice versa) has handicapped a full understanding of this relationship and perhaps efforts to bring resistance under control. In fact, this relationship is complicated. This article reviews factors that obscure detection of associations between antibiotic use and the emergence of resistance. It also provides a sample of the extensive data on this subject in the hope of encouraging the conduct of more sophisticated studies of the relationship between antibiotic use and the emergence of resistance. Such studies are necessary to provide institutions with the data they need to make informed decisions regarding antibiotic use.