Premium
Benefit of Ribose in a Patient with Fibromyalgia
Author(s) -
Gebhart Benjamin,
Jorgenson James A.
Publication year - 2004
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.24.16.1646.50957
Subject(s) - fibromyalgia , ribose , adenosine triphosphate , nucleotide , energy charge , adenosine , adenine nucleotide , adenosine monophosphate , energy metabolism , adenosine diphosphate , chemistry , medicine , regimen , adenylate kinase , endocrinology , biochemistry , enzyme , platelet , platelet aggregation , gene
Ribose was added to the existing treatment regimen of a woman with fibromyalgia, resulting in a decrease in symptoms. It has been postulated that patients with fibromyalgia may have an alteration in muscle adenine nucleotide metabolism, leading to depleted energy reserves and an imbalance in cellular adenosine 5′‐triphosphate:adenosine 5′‐diphosphate:adenosine 5′‐monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge. As a key component in adenine nucleotide synthesis, ribose supplementation may be useful in such patients.