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History of Depression as a Predictor of Adverse Outcomes in Patients Hospitalized for Decompensated Heart Failure
Author(s) -
Denus Simon,
Spinler Sarah A.,
Jessup Mariell,
Kao Andrew
Publication year - 2004
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.24.14.1306.43146
Subject(s) - medicine , acute decompensated heart failure , depression (economics) , heart failure , odds ratio , confidence interval , cardiopulmonary resuscitation , coronary care unit , intensive care unit , emergency medicine , medical history , intensive care medicine , cardiology , resuscitation , myocardial infarction , economics , macroeconomics
Study Objective. To evaluate the prevalence and impact of depression on the risk of in‐hospital death or need for cardiopulmonary resuscitation (CPR) in patients admitted for decompensated heart failure. Design. Observational single‐center study. Setting. Coronary care unit and cardiac intermediate‐care unit of a tertiary referral center. Patients. One hundred seventy‐one patients hospitalized with decompensated heart failure who were included in the Acute Decompensated Heart Failure Registry (ADHERE). Measurements and Main Results. The 34 patients with a history of depression had a higher likelihood of experiencing the combined end point of in‐hospital death or CPR compared with the 137 patients without a history of depression (17.7% vs 6.6%, p<0.05). A history of depression (odds ratio 3.3, 95% confidence interval 1.01–10.6, p<0.05) was still predictive of in‐hospital death or CPR in a multivariate analysis after adjusting for predictors of the combined end point. Conclusions. This study suggests that a history of depression is associated with an increased risk of in‐hospital mortality or CPR in patients hospitalized for decompensated heart failure. Our results require confirmation in larger trials.