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Nesiritide for Treatment of Heart Failure Due to Right Ventricular Dysfunction
Author(s) -
Sharp Randall P.,
Gregory Amy,
Mowdy Michael H.,
Sirajuddin Riaz
Publication year - 2004
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.24.13.1236.38092
Subject(s) - nesiritide , heart failure , diuresis , diuretic , medicine , cardiology , furosemide , intensive care medicine , natriuretic peptide , kidney
Little information exists regarding the use of nesiritide for treatment of right‐sided heart failure. Similarly, little information is available regarding routine use of combination nesiritide and diuretics as initial therapy to relieve edema due to heart failure. Nesiritide may be beneficial in combination with diuretics because it reduces activity of the renin‐angiotensin‐aldosterone system. It is unclear how potent nesiritide is as a diuretic. Patients exhibit wide variability in clinical response from the diuretic effects of the drug. Two patients were given a combination of nesiritide and diuretics as initial treatment of right‐sided heart failure; both experienced significant diuresis and weight loss. Further literature is needed to clarify the role of nesiritide in the treatment of right‐sided heart failure.