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Pharmacoepidemiology I: A Review of Pharmacoepidemiologic Study Designs
Author(s) -
Etminan Mahyar,
Samii Ali
Publication year - 2004
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.24.11.964.36143
Subject(s) - pharmacoepidemiology , observational study , medicine , clinical study design , research design , randomized controlled trial , cohort study , clinical trial , medical physics , pharmacology , statistics , medical prescription , mathematics
This article is the first of two parts on pharmacoepidemiology, a relatively new science that explores drug efficacy or toxicity using large observational study designs. The number of pharmacoepidemiologic studies published in medical journals has increased, as these studies have explored drug‐related questions that at times cannot be answered in randomized clinical trials. Four pharmacoepidemiologic study designs will be discussed that explore the association between a specific pharmacologic agent and a disease of interest: cohort studies, case‐control studies, case‐crossover studies, and case‐time‐control studies.