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Shock‐Like Sensations During Venlafaxine Withdrawal
Author(s) -
Reeves Roy R.,
Mack James E.,
Beddingfield John J.
Publication year - 2003
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.23.5.678.32198
Subject(s) - venlafaxine , discontinuation , anesthesia , reuptake inhibitor , shock (circulatory) , medicine , withdrawal syndrome , psychology , reuptake , serotonin , psychiatry , antidepressant , anxiety , receptor
Electric shock‐like sensations may occur after cessation of treatment with serotonin selective reuptake inhibitors but are reported in the literature only rarely with discontinuation of venlafaxine. Two patients experienced severe shock‐like sensations during venlafaxine withdrawal. For both patients symptoms occurred with lowering of the dosage and persisted for 5 days after complete discontinuation of the drug. These sensations may represent significant alteration of neuronal activity in the central nervous system.