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Pleconaril, a Novel Antipicornaviral Agent
Author(s) -
Florea Naomi R.,
Maglio Dana,
Nicolau David P.
Publication year - 2003
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.23.3.339.32099
Subject(s) - picornaviridae , rhinovirus , picornavirus , virology , medicine , pharmacokinetics , respiratory tract infections , virus , common cold , respiratory tract , pharmacology , immunology , biology , respiratory system , enterovirus , rna , biochemistry , gene
Despite the availability of therapy for selected symptoms, no specific antiviral agents are available to treat or prevent infections due to the viruses of the Picornaviridae family—rhinoviruses and enteroviruses. Characterization of the three‐dimensional structure of picornaviruses in the 1980s allowed development of compounds targeted at the virus itself. Pleconaril is a novel, orally available, systemically acting molecule whose pharmacokinetics are characterized by a two‐compartment open model with first‐order absorption and with a safety profile similar to that of placebo. It shows promising results in treatment of picornaviral respiratory tract infections, meningitis, and other life‐threatening infections.