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Moxifloxacin‐Induced Clostridium difficile ‐ Associated Diarrhea
Author(s) -
Carroll Douglas N.
Publication year - 2003
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.23.14.1517.31936
Subject(s) - moxifloxacin , diarrhea , medicine , metronidazole , clostridium difficile , antibiotic associated diarrhea , leukocytosis , pneumonia , abdominal pain , antibiotics , bacteroides fragilis , gastroenterology , intensive care medicine , microbiology and biotechnology , biology
A 22‐year‐old woman was admitted to the hospital with pneumonia, urinary tract infection, anemia, thrombocytopenia, and leukocytosis. After receiving moxifloxacin for 5 days, she experienced diarrhea with cramping and abdominal pain. She was diagnosed with Clostridium difficile ‐ associated diarrhea (CDAD) after C. difficile toxin was identified in a stool specimen. Metronidazole was begun, and the CDAD resolved with continued moxifloxacin administration. Virtually any antibiotic can lead to development of CDAD through disruption of the normal colonic flora, allowing for overgrowth of C. difficile . Although moxifloxacin is generally well tolerated, clinicians should be aware of its potential for inducing CDAD.