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Management of Severe Sepsis: Integration of Multiple Pharmacologic Interventions
Author(s) -
Micek Scott T.,
Shah Rina A.,
Kollef Marin H.
Publication year - 2003
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.23.14.1486.31945
Subject(s) - medicine , intensive care medicine , drotrecogin alfa , resuscitation , sepsis , psychological intervention , adrenal insufficiency , septic shock , intensive care , organ dysfunction , supportive psychotherapy , surviving sepsis campaign , early goal directed therapy , severe sepsis , surgery , nursing
Severe sepsis is an infection‐induced process that often promotes organ dysfunction and death in up to 50% of afflicted patients. Clinical advances that improve patient survival include early goal‐directed volume resuscitation, broad‐spectrum empiric antimicrobial therapy with deescalation strategies, therapy with drotrecogin alfa (activated), glucocorticoid replacement in patients with adrenal insufficiency, and tight control of blood glucose levels. The challenge for critical care practitioners is to integrate the many pharmacologic and supportive interventions required for optimal care of these patients.