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Clinical Issues Surrounding Once‐Daily Aminoglycoside Dosing in Children
Author(s) -
Knoderer Chad A.,
Everett Julie A.,
Buss William F.
Publication year - 2003
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.23.1.44.31924
Subject(s) - dosing , aminoglycoside , medicine , antibiotics , intensive care medicine , population , pediatrics , pharmacology , environmental health , biology , microbiology and biotechnology
Aminoglycoside antibiotics are first‐line treatment for many infectious diseases in the pediatric population and are effective in adults. The traditional dosing interval in children is every 8–12 hours. Studies in adults reported equivalent efficacy and equal or less toxicity with once‐daily regimens. Despite many studies in the adult population, this approach has yet to become standard practice in most pediatric hospitals. Reasons for lack of acceptance of this strategy in children include rapid aminoglycoside clearance, unknown duration of postantibiotic effect, safety concerns, and limited clinical and efficacy data.