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Neutropenia After Single‐Dose Clindamycin for Dental Prophylaxis
Author(s) -
Bubalo Joseph S.,
Blasdel Carolyn S.,
Bearden David T.
Publication year - 2003
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.23.1.101.31920
Subject(s) - neutropenia , medicine , clindamycin , absolute neutrophil count , febrile neutropenia , intensive care medicine , antibiotics , chemotherapy , microbiology and biotechnology , biology
A 68‐year‐old man with stable chronic myelogenous leukemia received a single dose of clindamycin before having a tooth extracted. He was neutropenic 6 days later, with an absolute neutrophil count of 945 cells/mm 3 . His neutrophil count returned to normal within 2 weeks. Clindamycin has been implicated in drug‐induced neutropenia; however, a review of the literature produced only three reports of this reaction. Only one provided the duration of the neutropenia. To our knowledge, this case report is only the second that provides the duration of the clindamycin‐induced neutropenia. Clinicians should be made aware of this potential adverse event.