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Warfarin Therapy and Risk of Hip Fracture Among Elderly Patients
Author(s) -
Mamdani Muhammad,
Upshur Ross E. G.,
Anderson Geoff,
Bartle Bill R.,
Laupacis Andreas
Publication year - 2003
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.23.1.1.31922
Subject(s) - warfarin , hip fracture , medicine , intensive care medicine , physical therapy , osteoporosis , atrial fibrillation
Study Objective. To ascertain the relationship between warfarin therapy and subsequent hip fracture in a large elderly population. Design. Retrospective, population‐based cohort study. Setting. Population‐based health care administrative databases for Ontario, Canada. Patients. Elderly patients receiving warfarin (52,701 patients), thyroid replacement therapy (40,555), an oral corticosteroid (43,915), or a proton pump inhibitor (60,383). The proton pump inhibitor group served as controls. Measurements and Main Results. The association between warfarin therapy and subsequent hospitalization for hip fracture in elderly patients was examined by researching administrative data from January 1, 1994‐March 31, 1999, for the elderly population of Ontario. Relative to patients receiving proton pump inhibitors, patients receiving warfarin (adjusted risk ratio [aRR] 0.94, 95% confidence interval [CI] 0.81–1.09) or thyroid replacement therapy (aRR 1.02, 95% CI 0.89–1.18) incurred similar risks of hip fracture. As expected, patients receiving oral corticosteroids incurred an increased risk (aRR 1.44, 95% CI 1.21–1.70) relative to patients receiving proton pump inhibitors. Conclusion. Warfarin was not associated with increased risk of hip fracture.