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Life‐Threatening Isradipine Poisoning in a Child
Author(s) -
Romano Michael J.,
Gaylor Allyson,
Sang Charlie J.
Publication year - 2002
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.22.9.766.34064
Subject(s) - isradipine , asystole , medicine , bradycardia , cardiopulmonary resuscitation , anesthesia , calcium channel blocker , calcium channel , resuscitation , dihydropyridine , calcium , heart rate , blood pressure
Calcium channel blockers as a group are responsible for significant morbidity and mortality with toxic exposures. Isradipine, a cardioselective dihydropyridine calcium channel blocker, rarely has been implicated, with only two reports in the literature of significant toxic reactions, one in an adult and another in a child. To our knowledge, we describe the first case of life‐threatening isradipine poisoning in a child and provide documentation of serum drug levels. On arrival at the hospital, a 5‐year‐old girl had abdominal distention and bradycardia that rapidly progressed to asystole. She received 73 minutes of cardiopulmonary resuscitation and transvenous cardiac pacing and survived with an intact neurologic recovery. Serum concentrations of isradipine were 30–100 times those found with therapeutic use.