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Syndrome of Inappropriate Antidiuretic Hormone‐Induced Hyponatremia Associated with Amiodarone
Author(s) -
Patel Gourang P.,
Kasiar Jennifer B.
Publication year - 2002
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.22.8.649.33206
Subject(s) - hyponatremia , amiodarone , medicine , discontinuation , syndrome of inappropriate antidiuretic hormone secretion , adverse effect , antidiuretic , vasopressin , endocrinology , anesthesia , atrial fibrillation
The syndrome of inappropriate antidiuretic hormone (SIADH), the most common cause of euvolemic hyponatremia, is due to nonphysiologic release of arginine vasopressin from the posterior pituitary. Hyponatremia induced by SIADH can be caused by several conditions, such as central nervous system disorders, malignancies, various nonmalignant lung diseases, hypoadrenalism, and hypothyroidism. A 67‐year‐old man developed hyponatremia consistent with SIADH. Although common comorbid conditions associated with SIADH were excluded as possible causes, his medical history and drug regimen were extensive. However, he had been taking spironolactone, amiodarone, and simvastatin for less than 3 months. Amiodarone was discontinued based on a case report suggesting that this drug can cause SIADH‐induced hyponatremia. The patient's serum sodium level began to rise within 3 days of discontinuation and returned to normal within 1 month. Although SIADH‐induced hyponatremia occurs only rarely, it should be recognized as a possible adverse effect of amiodarone.