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Rabbit Syndrome Secondary to Risperidone
Author(s) -
Hoy Jenifer S.,
Alexander Bruce
Publication year - 2002
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.22.7.513.33669
Subject(s) - risperidone , olanzapine , antipsychotic , anticholinergic , medicine , atypical antipsychotic , extrapyramidal symptoms , side effect (computer science) , dopamine antagonist , dopamine receptor d2 , pediatrics , dopamine , pharmacology , psychology , psychiatry , schizophrenia (object oriented programming) , haloperidol , computer science , programming language
After taking risperidone for 4 months, a 38‐year‐old man with a major depressive disorder experienced rabbit syndrome. This uncommon extrapyramidal side effect is characterized by rhythmic movements of the mouth and may be caused by typical antipsychotics and risperidone secondary to blockade of dopamine D 2 receptors. The syndrome, whose exact mechanism is unknown, responded to anticholinergic treatment in this patient. A literature review indicated that most recent cases have occurred as reactions to the atypical antipsychotic risperidone. Changing treatment to an atypical antipsychotic other than risperidone, such as olanzapine 10 mg/day, may lead to suppression or elimination of the syndrome.