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Potential Anaphylactic Shock with Abciximab Readministration
Author(s) -
Pharand Chantal,
Palisaitis Donald A.,
Hamel Denis
Publication year - 2002
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.22.5.380.33196
Subject(s) - medicine , diphenhydramine , anesthesia , anaphylaxis , epinephrine , cetirizine , sodium bicarbonate , ranitidine , histamine , pharmacology , allergy , chemistry , immunology
A 46‐year‐old woman developed an anaphylactic reaction during percutaneous coronary intervention after she was pretreated with prednisone and diphenhydramine for a known allergy to iodine. She developed pruritus, edema, and nausea, which were followed by bradycardia and shock, minutes after administration of a bolus and standard‐dose infusion of abciximab. The reaction was treated successfully with epinephrine, methoxamine, hydrocortisone, atropine, furosemide, sodium bicarbonate, diphenhydramine, and ranitidine.