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Levofloxacin and Warfarin Interaction
Author(s) -
Ravnan Susan L.,
Locke Christy
Publication year - 2001
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.21.9.884.34559
Subject(s) - levofloxacin , warfarin , medicine , drug interaction , warfarin sodium , ciprofloxacin , pharmacology , pharmacokinetic interaction , antibiotics , pharmacokinetics , atrial fibrillation , microbiology and biotechnology , biology
Numerous case reports have documented an enhanced hypoprothrombinemic effect caused by an interaction between fluoroquinolones (most notably, ciprofloxacin) and warfarin sodium. Conflicting data exist regarding the clinical significance of this interaction. Two patients who had elevated international normalized ratios after receiving concurrent levofloxacin and warfarin sodium are described.