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Update on Strategies to Improve Thrombolysis for Acute Myocardial Infarction
Author(s) -
Spinler Sarah A.,
Inverso Stephanie M.
Publication year - 2001
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.21.7.691.34579
Subject(s) - medicine , thrombolysis , myocardial infarction , heparin , cardiology , percutaneous coronary intervention , reperfusion therapy , intensive care medicine
Therapy for acute myocardial infarction involves rapid restoration of blood flow through a coronary artery that has been occluded by a ruptured atherosclerotic plaque. Thrombolytic therapy, the pharmacologic standard to achieve this outcome, significantly improves survival; however, current regimens have limitations: they can fail to achieve complete reperfusion, they can cause significant bleeding events, and they can result in reocclusion. In addition, complex regimens of some agents can cause dosing errors. Accordingly, newer compounds were developed to address some of these issues, and alternative strategies are being implemented. The combination of platelet glycoprotein IIb‐IIIa receptor inhibitors plus thrombolytic agents produced promising results in clinical trials, including faster clot lysis and greater flow rates than either therapy alone. The addition of unfractionated heparin or low‐molecular‐weight heparin to thrombolytic‐antiplatelet therapy is being evaluated, as is administration of thrombolytic‐antiplatelet before percutaneous coronary intervention.