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Colestipol‐Induced Hepatotoxicity
Author(s) -
Sirmans Susan M.,
Beck Joni K.,
Banh Hoan Linh,
Freeman Dale A.
Publication year - 2001
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.21.5.513.34501
Subject(s) - medicine , gastroenterology , asymptomatic , bile acid , dyslipidemia , transaminase , liver function tests , liver function , elevated transaminases , hepatic function , liver damage , alanine transaminase , chemistry , biochemistry , enzyme , obesity
A 65‐year‐old man with type IIa dyslipidemia who received flavored colestipol granules 2 scoops/day for 3 months developed asymptomatic hepatotoxicity. Several of his liver enzymes were elevated 10 times the upper limit of normal. One week after discontinuing colestipol, serum transaminases fell dramatically, with some returning to normal limits. Four weeks after colestipol was discontinued, all liver function tests were normal. Rechallenge was not attempted. Other potential causes of hepatocellular injury were evaluated. Bile acid‐binding resins commonly are administered to treat type IIa dyslipidemia. Despite extensive use of the resins, significant elevations of transaminase levels are rare. Because the exact mechanism of bile acid resin‐induced hepatotoxicity is unknown, high‐risk patients may require liver function test monitoring and education on hepatotoxic side effects.