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Idiosyncratic Rifabutin‐Induced Leukopenia and SIADH: Case Report and Review
Author(s) -
Chitre Mona M.,
Berenson Charles S.
Publication year - 2001
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.21.5.493.34488
Subject(s) - rifabutin , leukopenia , medicine , toxicity , clarithromycin , helicobacter pylori
Rifabutin is increasingly critical for treatment of atypical mycobacterial infections. One of its serious adverse effects is leukopenia. When encountering rifabutin‐induced leukopenia, clinicians are faced with the dilemma of whether to lower the dosage of rifabutin or discontinue it because existing literature does not indicate whether rifabutin‐induced leukopenia is dose related or idiosyncratic. We report the first established case of idiosyncratic rifabutin‐induced leukopenia in an immunocompetent man treated for pulmonary Mycobacterium avium complex infection. The patient also developed rifabutin‐induced syndrome of inappropriate antidiuretic hormone (SIADH), which also has not been previously reported.