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Triiodothyronine Supplementation in Patients Undergoing Cardiopulmonary Bypass
Author(s) -
Reichert Marc G.,
Verzino Kelly C.
Publication year - 2001
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.21.17.1368.34425
Subject(s) - cardiopulmonary bypass , triiodothyronine , medicine , hormone , cardiac surgery , thyroid , perioperative , cardiology , atrial fibrillation , thyroid function , thyroid hormones , endocrinology , anesthesia
Patients undergoing cardiopulmonary bypass may develop clinically significant physiologic alterations in the perioperative period, including alteration of thyroid hormone concentrations. Alterations in the concentration of thyroid hormones are of concern due to the effects of these hormones on cardiac function. Hypothyroidism is associated with a decrease in cardiac performance; therefore, supplementation with the active thyroid hormone triiodothyronine (T 3 ) in patients undergoing cardiopulmonary bypass has been investigated to improve outcomes. In addition, T 3 has been studied as an agent to reduce the frequency of atrial fibrillation after cardiopulmonary bypass.