Premium
Suspected Allopurinol‐Induced Aseptic Meningitis
Author(s) -
Greenberg Laurie E.,
Nguyen Thuy,
Miller Susan M.
Publication year - 2001
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.21.11.1007.34526
Subject(s) - aseptic meningitis , medicine , allopurinol , meningitis , pleocytosis , adverse effect , etiology , surgery , intensive care medicine , pediatrics
Drug‐induced aseptic meningitis is a syndrome with symptoms similar to those of infectious meningitis. A 60‐year‐old man with a history of recurrent renal stones was admitted to the hospital with fever, chills, and mental status changes after taking levofloxacin, allopurinol, and acetazolamide. No infectious source was identified. Once home, he resumed allopurinol, and within 2 hours, he experienced the same symptoms, requiring rehospitalization. He was diagnosed with suspected meningitis from an adverse drug reaction that we believe was due to allopurinol. It is important to remember, when all other causes are ruled out, that a patient's symptoms may be a drug‐induced adverse effect. Drug‐induced aseptic meningitis should be considered when patients with symptoms similar to those of infectious meningitis appear without infectious etiologies or cerebrospinal fluid pleocytosis, a suspected agent was recently started, and resolution of adverse effects occurs when the agent is withdrawn.