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Thrombocytopenia Associated with Intravenous Ciprofloxacin
Author(s) -
Starr Jessica A.,
Ragucci Kelly R.
Publication year - 2005
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.2005.25.7.1030
Subject(s) - ciprofloxacin , medicine , intravenous antibiotics , intravenous drug , intensive care medicine , antibiotics , microbiology and biotechnology , virology , biology , human immunodeficiency virus (hiv) , viral disease
A variety of disease states, disorders, hereditary conditions, environmental toxins, and drugs may cause thrombocytopenia. Fluoroquinolones, however, are not thought to be common offenders. We report the case of a 72‐year‐old woman who was receiving intravenous ciprofloxacin for a urinary tract infection and developed thrombocytopenia during her hospital stay. Her platelet count dropped from 147 times 10 3 /mm 3 on admission to as low as 21 times 10 3 /mm 3 . On discontinuation of the drug, her platelet counts began to return to normal. After discharge, the patient continued to improve clinically. Four days after discharge, her platelet count was 197 times 10 3 /mm 3 . In the primary literature, we found two case reports on thrombocytopenia associated with ciprofloxacin and one case report with alatrofloxacin. In addition, six additional case reports were found in non‐English journals that describe fluoroquinolone‐associated thrombocytopenia. Clinicians should be aware of the possible relationship between thrombocytopenia and fluoroquinolones, and platelet counts should monitored accordingly.