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Relationship between Benign Prostatic Hyperplasia and History of Coronary Artery Disease in Elderly Men
Author(s) -
Weisman Kenneth M.,
Larijani Ghassem E.,
Goldstein Mark R.,
Goldberg Michael E.
Publication year - 2000
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.20.5.383.35053
Subject(s) - medicine , coronary artery disease , myocardial infarction , diabetes mellitus , cardiology , hyperplasia , artery , angioplasty , urology , endocrinology
Study Objective. To assess the relationship between the occurrence of benign prostatic hyperplasia (BPH), an androgen‐dependent disease, and coronary artery disease (defined as history of coronary artery bypass grafting, coronary angioplasty, myocardial infarction) in elderly men. Design. Retrospective chart review. Setting. Urology practice. Patients. Seven hundred two elderly men aged 65–80 years. Intervention. The men's charts were reviewed for data pertaining to coronary artery disease, risk factors for coronary artery disease, and serum prostate‐specific antigen (PSA) levels. Men who had medical conditions, pharmacologic interventions, or surgical procedures that could alter PSA, and those taking lipid‐lowering agents were not included. Measurements and Main Results. PSA levels correlate positively with prostatic volume of BPH. In men with levels under 1.0 μg/L (no BPH) and over 1.0 μg/L (BPH present), the frequency of coronary artery disease was 9% and 29%, respectively (p<0.03). No significant differences were noted between groups in other accepted risk factors for coronary artery disease including age, smoking, diabetes mellitus, or hypertension. Conclusion. Smooth muscle proliferation is an important and possibly androgen‐dependent step in the development of atherosclerosis and BPH. Prospective studies are required to assess the effect of antiandrogens on atherosclerosis.