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Treatment of Pediatric Hypertension
Author(s) -
Temple Mary E.,
Nahata Milap C.
Publication year - 2000
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.20.3.140.34782
Subject(s) - medicine , nicardipine , labetalol , pharmacotherapy , randomized controlled trial , medline , clinical trial , intensive care medicine , drug , pharmacology , blood pressure , political science , law
We conducted a MEDLINE search from January 1966—March 1999 to obtain information on clinical trials of treatment of pediatric hypertension. An article was selected for review if it described a randomized or nonrandomized study; randomized studies were given priority. Case reports were considered when studies were unavailable. Review articles were useful in identifying references. According to data we collected, hypertension is present in 1–3% of the pediatric population. Nonpharmacologic treatment may be effective initially in those with mild to moderate disease or as an adjunct to drug therapy. Drugs for treatment of chronic hypertension include calcium channel blockers, angiotensin‐converting enzyme inhibitors, diuretics, and β‐blockers. Patient and drug characteristics determine therapy. Intravenous labetalol, nicardipine, and nitroprusside are effective for treating hypertensive emergencies.