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Anaphylactoid Reaction to Levofloxacin
Author(s) -
Smythe Maureen A.,
Cappelletty Diane M.
Publication year - 2000
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.20.19.1520.34868
Subject(s) - levofloxacin , chemistry , medicine , biochemistry , antibiotics
Anaphylactoid and/or anaphylactic reactions to fluoroquinolones are estimated to occur in 0.46–1.2/100,000 patients. A 49‐year‐old woman with a history of asthma was admitted for a presumed asthma exacerbation related to an infectious process. She was given levofloxacin and standard management for an acute exacerbation. On two occasions the patient's respiratory distress worsened, requiring intubation. The second reaction occurred immediately after levofloxacin administration and was accompanied by a marked cutaneous reaction. Levofloxacin was discontinued, and supportive care was provided. No further symptoms occurred. The patient later was found to have been started on levofloxacin before admission for a suspected upper respiratory infection.