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Mefloquine‐Induced Acute Hepatitis
Author(s) -
Gotsman Israel,
AzazLivshits Tanya,
Fridlender Zvi,
Muszkat Mordechai,
BenChetrit Eldad
Publication year - 2000
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.20.19.1517.34856
Subject(s) - mefloquine , medicine , malaria , liver function tests , liver function , drug , hepatitis , malaria prophylaxis , plasmodium falciparum , liver disease , acute hepatitis , gastroenterology , pharmacology , immunology
Mefloquine is an effective drug for prophylaxis and treatment of malaria caused by Plasmodium falciparum . It is generally well tolerated with few side effects. Minimal elevation of liver function tests has been reported after exposure to mefloquine, especially in susceptible individuals with prior abnormal liver function tests. Our patient, who had had elevated liver function tests attributed to heart failure, experienced an acute elevation of liver transaminases 6 weeks after exposure to mefloquine 250 mg/week. Cessation of the drug caused test results to return to normal. Mefloquine should be prescribed cautiously in patients with liver disease.