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Potentiation of Warfarin's Hypoprothrombinemic Effect with Miconazole Vaginal Suppositories
Author(s) -
Thirion Daniel J. G.,
Zanetti Leslie A. Farquhar
Publication year - 2000
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.20.1.98.34665
Subject(s) - miconazole , ecchymosis , warfarin , medicine , prothrombin time , anesthesia , vaginal bleeding , pharmacology , surgery , antifungal , dermatology , atrial fibrillation , pregnancy , biology , genetics
A 53‐year‐old woman being treated for a vaginal yeast infection experienced ecchymosis. Laboratory evaluation revealed a prolonged prothrombin time. It is possible that the bleeding was due to an interaction between warfarin and miconazole. Health care professionals should be aware of the potential for drug interactions with vaginally administered miconazole, especially in women receiving anticoagulation therapy.