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Effect of Gender on the Pharmacokinetics of Ofloxacin
Author(s) -
Sowinski Kevin M.,
Abel Steven R.,
Clark William R.,
Mueller Bruce A.
Publication year - 1999
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.19.6.442.31044
Subject(s) - ofloxacin , pharmacokinetics , pharmacology , medicine , chemistry , antibiotics , biochemistry , ciprofloxacin
Study Objectives . To assess the influence of gender on the pharmacokinetics of ofloxacin. Design . Open‐label study. Setting . Academic medical center. Patients . Five healthy men and seven healthy women volunteers. Interventions . Subjects received a single oral dose of ofloxacin 400 mg, and serial blood samples were collected for 24 hours. Plasma concentrations of ofloxacin were determined by high‐performance liquid chromatography and pharmacokinetic parameters were determined. Statistical comparisons between genders were made with the Wilcoxon rank sum test. Measurements and Main Results . Median volume of distribution at steady state/systemic bioavailability (V ss /F) was significantly smaller in women than in men, although when normalized for total body weight there were no differences. Except for terminal elimination half‐life, which was 10% shorter in women, no other pharmacokinetic values were significantly different between genders. Median peak concentrations, although not statistically different, were 28% higher in women. Conclusion . Ofloxacin V ss /F values were smaller in women than in men, explained by gender‐related differences in weight.