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Quality of Life as a Treatment Outcome in Patients with Cystic Fibrosis
Author(s) -
Munzenberger Paul J.,
Wagnen Catherine A.,
Abdulhamid Ibrahim,
Walker Paul C.
Publication year - 1999
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.19.6.393.31047
Subject(s) - cystic fibrosis , quality of life (healthcare) , medicine , outcome (game theory) , intensive care medicine , nursing , mathematics , mathematical economics
We attempted to determine the responsiveness and validity of the Quality of Well‐Being (QWB) scale in 20 consecutive children and adolescents with cystic fibrosis. The QWB score was determined for 6‐day periods immediately before and after hospital admission, and at 6‐ and 12‐month follow‐up. With the instrument's scale of zero‐1, responsiveness was indicated by significant changes in QWB score (0.09), physical (0.019), social (0.021), and symptom‐problem complexes (0.04) domains, and all pulmonary function tests from before to after treatment of an acute exacerbation. Only the symptom‐problem complex domain significantly changed from after treatment to 6‐ and 12‐month follow‐up. Validity was shown by significant correlations between before and after QWB scores and forced vital capacity (r=0.476), residual volume total lung capacity ratio (r=0.452), forced expiratory volume in 1 second (r=0.358), and forced expiratory flow between 25% and 75% of vital capacity (r=0.35).