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Nonchemotherapy Drug‐Induced Agranulocytosis: A Review of 118 Patients Treated with Colony‐Stimulating Factors
Author(s) -
Beauchesne MarieFrance,
Shalansky Stephen J.
Publication year - 1999
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.19.4.299.30941
Subject(s) - discontinuation , neutropenia , medicine , granulocyte colony stimulating factor , drug , absolute neutrophil count , mortality rate , toxicity , pharmacology , chemotherapy
To determine the role of growth factors in nonchemotherapy drug‐induced agranulocytosis, we reviewed 118 published reports of administration of colony‐stimulating factors for the disorder. Main outcomes were total duration of neutropenia and mortality. The mean time to neutrophil recovery was 4.6 ± 3.2 days and 7.7 ± 5.1 days in patients with a granulocyte count at diagnosis of 0.1‐0.5 × 10 3 /mm 3 and less than 0.1 × 10 3 /mm 3 , respectively. The mortality rate was 4.2%. Without therapy with growth factors, the mean time to neutrophil recovery after discontinuation of the offending agent was reported to be 10 ± 8 days. The mortality rate was 16% in one study. We conclude that hematopoietic growth factors may shorten the duration of neutropenia and reduce mortality in patients with severe drug‐induced agranulocytosis.