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Judicious Evaluation of Adverse Drug Reactions: Inaccurate Assessment of 3‐hydroxy‐3‐methylglutaryl Coenzyme A Reductase Inhibitor‐Induced Muscle Injury
Author(s) -
Dietz Brenda L.,
Oberg Kristin C.
Publication year - 1999
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.19.3.232.30924
Subject(s) - atorvastatin , rhabdomyolysis , myalgia , adverse effect , medicine , drug , adverse drug reaction , reductase , epicondylitis , forearm , simvastatin , coenzyme a , pharmacology , surgery , chemistry , biochemistry , enzyme , elbow
Adverse reactions in two patients who received HMG CoA reductase inhibitor therapy were reinvestigated because of their rarity. A case of permanent forearm myalgia was thought to be caused by atorvastatin. Closer evaluation and work‐up revealed underlying lateral epicondylitis, and atorvastatin was not considered the cause of the disability. In another patient, rhabdomyolysis was suspected to be secondary to simvastatin. However, after an extensive review, the reaction was believed to be compartment syndrome of the anterior tibial area. An adverse drug reaction report requires careful and judicious assessment to assign the correct probability for the event.