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Peripheral Neuropathy in Healthy Men Volunteers Anesthetized with 1.25 MAC Sevoflurane for 8 Hours
Author(s) -
Goldberg Michael E.,
Larijani Ghassem E.,
Eger Edmond I
Publication year - 1999
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.19.15.1173.30573
Subject(s) - sevoflurane , medicine , anesthesia , peripheral , peripheral neuropathy , endocrinology , diabetes mellitus
Two men volunteers developed peripheral neuropathy after prolonged anesthesia with 1.25 minimum alveolar concentration sevoflurane at an inflow rate of 2 L/minute of fresh gas that caused concurrent administration of relatively large doses (ppm‐hrs) of the degradation product of sevoflurane, compound A. Other similarly treated volunteers had lesser degrees of transient neuropathy. This result does not prove but raises the question of whether compound A or other factors associated with sevoflurane anesthesia can predispose patients to peripheral neuropathy.