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Vinorelbine Tartrate‐Induced Pulmonary Edema Confirmed on Rechallenge
Author(s) -
Cattan Christine E.,
Oberg Kristin C.
Publication year - 1999
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.19.11.992.31580
Subject(s) - vinorelbine , medicine , furosemide , pulmonary edema , anesthesia , edema , vasodilation , lung , chemotherapy , cisplatin
A 67‐year‐old woman with metastatic breast cancer experienced sudden and profound pulmonary edema within 45 minutes after completion of intravenous administration of vinorelbine tartrate on two occasions. Both times the drug was discontinued and the patient was treated aggressively with oxygen, intravenous furosemide, and a vasodilator. The patient suffered no lasting medical complications due to the reaction. Until clear documentation and the mechanism for occurrence of this reaction are known, patients receiving vinorelbine should be monitored closely, particularly in the first few hours after intravenous administration.