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Abacavir: Absolute Bioavailability, Bioequivalence of Three Oral Formulations, and Effect of Food
Author(s) -
Chittick Gregory E.,
Gillotin Catherine,
McDowell James A.,
Lou Yu,
Edwards Kathleen D.,
Prince William T.,
Stein Daniel S.
Publication year - 1999
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1592/phco.19.11.932.31568
Subject(s) - bioequivalence , abacavir , bioavailability , pharmacokinetics , crossover study , pharmacology , medicine , chemistry , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load , virology , placebo , alternative medicine , pathology
Study Objectives. Study A: to determine the absolute bioavailability of a single 300‐mg abacavir hemisulfate tablet. Study B: to determine the bioequivalence of two oral abacavir formulations (300‐mg hemisulfate tablet, 100‐mg succinate caplet), the effect of food on the bioavailability of the 300‐mg hemisulfate tablet, and the bioavailability of the hemisulfate tablet relative to the hemisulfate solution. Design. Phase I, randomized, open‐label, balanced two‐ (study A) and three‐or four‐period (study B), crossover studies. Setting. Two clinical research centers. Subjects. Six men infected with the human immunodeficiency virus (HIV), aged 27–39 years (study A), and 18 HIV‐infected men and women, aged 21–50 years (study B). Interventions. In study A, all subjects received a single, oral 300‐mg tablet of abacavir hemisulfate or a single, intravenous infusion of abacavir hemisulfate 150 mg over 60 minutes. In study B, all subjects received each of three single‐dose treatments: three 100‐mg abacavir succinate caplets in a fasted state, one 300‐mg abacavir hemisulfate tablet in a fasted state, and one 300‐mg abacavir hemisulfate tablet with a high‐fat breakfast. Twelve subjects in study B also received a fourth treatment of abacavir hemisulfate 300 mg as an oral solution in a fasted state. Plasma samples collected for 24 hours (study A) or 12 hours (study B), and urine samples collected for 12 hours (study A) were analyzed by validated high‐performance liquid chromatographic methods. Measurements and Main Results. Abacavir pharmacokinetic parameters were calculated using standard, noncompartmental methods. In study A, the geometric least square (GLS) mean absolute bioavailability of oral abacavir was 83% (range 65–107%). In study B, the hemisulfate tablet was bioequivalent to the succinate caplet, but its time to maximum concentration (T max ) occurred 30 minutes earlier. Administration of the abacavir hemisulfate tablet with food had no effect on area under the curve from time zero to infinity (AUC 0–∞ ), decreased maximum concentration (C max ) by 26%, and delayed T max by 38 minutes. The relative bioavailability (GLS mean AUC 0–∞ ratio) of the 300‐mg abacavir hemisulfate tablet to solution was 101%, C max was 11% lower, and T max was unchanged. The most common drug‐related adverse events associated with abacavir were nausea, vomiting, abdominal pain, and headache, all of which were mild. Conclusion. Based on our results, abacavir is safe and well tolerated and can be administered with or without meals.

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