Open AccessAvaliação da eficácia do colostro bovino hiperimune na infecção experimental de roedores com Cryptosporidium parvum
Author(s) -
Vicente José Salles de Abreu,
Ary Lopes Cardoso,
Hilda Fátima de Jesus Pena,
Solange María Gennari,
Idércio Luiz Sinhorini,
Sylvie Damy
Publication year - 2003
Publication title -
brazilian journal of veterinary research and animal science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.187
H-Index - 17
eISSN - 1678-4456
pISSN - 1413-9596
DOI - 10.1590/s1413-95962003000900006
Subject(s) - cryptosporidium parvum , biology , virology
The hyperimmune bovine colostrum has a high concentration of antibodies anti-Cryptosporidium parvum. This product is considered one of the promising therapeutic strategies in the control of intestinal cryptosporidiosis in humans. With the purpose to evaluate the hyperimmune bovine colostrum efficacy in reducing the parasitism and preventing intestinal mucosa alterations, several strains of rats F344 and mice were experimentally infected with Cryptosporidium parvum oocysts. The results showed that the hyperimmune bovine colostrum had high levels of antibodies. The rats F344, treated either with hyperimmune or normal bovine colostrum, had reduction of the intestinal parasitism and presented little mucosa compromise. The mice C57BL/6 when treated either with hyperimmune or normal colostrum had slight reduction of the intestinal parasitism and evidenced no statistical significant differences in the histopathological mucosa changes. In conclusion, the use of hyperimmune bovine colostrum has a limited benefit in Cryptosporidium parvum infection